The ARUBA study is a multi-institutional randomized controlled trial that compared the risk of death and symptomatic stroke in patients with unruptured AVMs. Patients were randomized in a 1:1 ratio to medical management versus interventional therapy plus medical management. The intervention given to the patient (surgical removal, embolization, stereotactic radiosurgery [SRS], or a combination of these) was left to the discretion of the individual practitioners. The study was closed to accrual early when it reached prespecified stopping rules, with results suggesting the superiority of the medical management group. At that time, 114 patients were assigned to interventional therapy and 109 to medical management. The risk of death or stroke was significantly lower in the medical management group than in the interventional group (hazard ratio, 0.27; P < .0001).
Management of unruptured AVMs: the pendulum swings / Chan, M. D.; Soltys, S. G.; Halasz, L. M.; Laack, N. N.; Minniti, G.; Kirkpatrick, J. P.. - In: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS. - ISSN 0360-3016. - 105:4(2019), pp. 687-689. [10.1016/j.ijrobp.2019.08.026]
Management of unruptured AVMs: the pendulum swings
Minniti G.Penultimo
;
2019
Abstract
The ARUBA study is a multi-institutional randomized controlled trial that compared the risk of death and symptomatic stroke in patients with unruptured AVMs. Patients were randomized in a 1:1 ratio to medical management versus interventional therapy plus medical management. The intervention given to the patient (surgical removal, embolization, stereotactic radiosurgery [SRS], or a combination of these) was left to the discretion of the individual practitioners. The study was closed to accrual early when it reached prespecified stopping rules, with results suggesting the superiority of the medical management group. At that time, 114 patients were assigned to interventional therapy and 109 to medical management. The risk of death or stroke was significantly lower in the medical management group than in the interventional group (hazard ratio, 0.27; P < .0001).| File | Dimensione | Formato | |
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